20 Best Acne Spot Treatments Rated by Beauty Experts

20 Best Acne Spot Treatments Rated by Beauty Experts

PUBLISHED: 07/05/2019 | LAST UPDATED: 01/16/2020


Licensed Aesthetician 

This article may contain affiliate links. Please read our disclosure policy for more details. To learn more about how we selected the products featured on this list, check out our product review & research standards.

What do 40 million+ people in the United States have in common? Here’s a hint for you… it’s a condition that occurs when the pores become clogged with oil, bacteria, and dead skin cells. Of course, we’re talking about acne.

Whether you or someone you know suffers from acne, there are two ways to approach a sudden acne breakout: 1) reach for a “quick fix” over-the-counter acne spot treatments that simply mask the problem and can even cause major skin dryness and irritation or 2) try using a natural acne spot treatment which will treat your acne from the inside out. 

What’s In Your Acne Spot Treatment?
Quick fix acne spot treatment solutions use cheap and overly potent ingredients like ultra-drying denatured alcohol and damaging synthetic acids to quickly “solve” the breakout. While denatured alcohol works wonders to remove excess oil and kill acne-causing bacteria, it can also damage your skin’s acid mantle, throw off your pH balance, and (as a result) cause further dryness and breakouts. What you get in short-term effectiveness, you give up in the long-term beauty of your skin. 

Additionally, many acne spot treatments available today are packed with water, preservatives, and tons of cheap fillers that offer no real benefit to your skin. You have to ask yourself, what are you really paying for?

The solution? Try an acne spot treatment made from incredibly potent acne-fighting ingredients that are also nourishing for your skin! Forgoing harsh and drying alcohol-based acne treatments for an all natural acne spot treatment doesn’t mean that you have to make trade-offs for effectiveness. In our over eight month trial of testing natural acne spot treatments, we found several natural products that worked shockingly well at removing blemishes. You just have to know which acne spot treatments are using high-quality ingredients and which ones are just selling snake oil. 

Best Acne Spot Treatment Ingredients
The best acne spot treatments on the market take advantage of naturally powerful anti-inflammatory, anti-bacterial, and antimicrobial plant oils, waxes, and acids. Some of the most effective natural acne spot treatment ingredients are:

  • Black Cumin Seed
  • Cajeput
  • Tea Tree Oil
  • Willow Bark/Salicylic Acid
  • Honey
  • Green Tea
  • Neem
  • Grapeseed, Jojoba, & Sunflower Oils 
  • Rose Oil
  • Aloe Vera
  • Turmeric

These ingredients offer a range of benefits as acne spot treatments. Ingredients like honey, tea tree oil, rose oil, and neem have potent antibacterial properties while also having skin-protecting abilities as well. Grapeseed oil, aloe, and turmeric work well at reducing the redness and inflammation that generally occurs along with breakouts. Grapeseed, jojoba, and sunflower oil are non-comedogenic, so they can hydrate the skin without clogging pores. 

Note: Acne can be caused by a variety of issues ranging from lifestyle choices to environmental stressors. If you acne is caused by lifestyle choices (for example, poor diet), then there is little an acne spot treatment can do in the long-term to prevent future breakouts. Acne spot treatments are great for temporary flare-ups caused by hormones, clogged pores, and oily skin. Ultimately, if you want to prevent breakouts you should look to address the root cause of your acne. For more information, see our “Major Causes of Acne” section at the bottom of this article. 

Finding The Best Acne Spot Treatment
To help you discover truly effective acne spot treatments that are bursting with natural ingredients, our team went out and tested over 100 different acne spot treatments to bring you this list of the very best. Each acne spot treatment on this list was thoroughly researched and vetted for effectiveness, ingredient quality, and brand reputation. Not only did our team try these spot treatments themselves, they also researched third party reviews and customer reviews online. In short, whether you have hormonal acne, cystic acne, or just the occasional blemish, there is an acne spot treatment for you on this list. There are even a few natural overnight acne spot treatments for those who need results fast. Enjoy!



Need help finding the perfect natural acne spot treatment for your skin? Take our Acne Spot Treatments Quiz & get matched with the best organic and all natural spot treatments for you! We've created a custom quiz to help you quickly find the top 5 products from our list. Takes just a few seconds to complete---click to get started.

*Odacite – BL + C Natural Acne Spot Treatment ($36)

This miracle serum is formulated specifically for problematic skin, and works to reduce the appearance of blemishes. Containing just three ingredients—purifying black cumin oil, cleansing cajeput oil, and soothing vitamin E—this blend is so potent you only need a couple of drops to see results. Whether used as a preventative serum or as a spot treatment, this formula treats and calms, leaving behind a clean and clear complexion. A little goes a long way, feels light on the skin and it even smells nice.

*Pai Skin Care – Copaiba & Zinc Natural Acne Serum ($78)

Pai is a skin care line focused on providing effective natural products for those with sensitive skin. This blemish serum works to kill acne-causing bacteria, reduce redness, and clear congested pores all while hydrating the skin. Star ingredients like copaib and zinc PCA (antibacterial and protective) work together to tackle every challenge of sensitive acne-prone skin. Made without harsh chemicals or fragrances! It has a light citrus scent from natural essential oils of orange and lemon.

*Juice Beauty – Organic Acne Clearing Serum ($30)

An organic solution to annoying breakouts and oily complexion. This natural acne treatment is created with organic fruit juices to cleanse and hydrate the skin and sweep away acne-causing bacteria. Contains willow bark with natural salicylic acid to prevent and clear breakouts and CoQ10, Vitamin C and organic aloe to renew the skin for a healthy, clear complexion. Ideal for all skin types, this serum is easy to apply and a little goes a long way. Moisturize after use as it may leave skin dry.

*Kypris – Organic Acne Clearing Serum ($90)

This acne clearing serum is supercharged with zinc and lilac leaf stem cells to balance oily complexions and reduce the appearance of blemishes, as well as a blend of astringent essential oils like tea tree and lavender to help prevent them in the first place. Packaged in a glass bottle and suitable for most skin types, especially those with fussy, pollution-irritated or hormonal skin. Formulated to support the skin’s inherent healing capabilities to minimize the appearance of blemishes.

*Vered Organic Botanicals – Therapeutic Organic Acne Treatment Oil ($88)

A heavenly therapeutic blend of organic ingredients formulated to balance sebum production and help calm inflammation. Ideal for normal to problematic skin, this acne treatment facial serum is packed with healing ingredients like chickweed (eliminates blemish-causing bacteria), speedwell (anti-inflammatory and antiseptic) and black cumin seed oil (promotes healing, fights acne and leaves skin soft). It smells as amazing as it feels on the skin and it’s free of all synthetics and harsh chemicals.

*Osmia Organics – Balance Natural Acne Treatment Serum ($50)

A favorite oily and combination skin treatment, this serum brings skin back into natural balance. Absorbing quickly, it regulates sebum production to help oily skin act less oily and combination skin self-regulate. Blended with skin nourishing ingredients like squalene oil (deeply hydrates), rosehip extract (helps protect skin against environmental stressors) and rosemary extract (increases circulation and blood flow), this organic acne spot treatment enables you to enjoy fewer breakouts.


Make sure that the next natural acne spot treatment that you buy is the right one for your skin! Get matched to your perfect organic acne spot treatment in seconds with our Acne Spot Treatments Quiz. Click now to get started.

The Major Causes of Acne Breakouts

Acne is almost always manifested from poor lifestyle choices, environmental toxins, or stress. Because of this, we can’t possibly generalize “one central reason” for acne. Contrary to popular belief, acne is not simply caused by clogged pores. While clogged pores do create the perfect environment for acne-causing bacteria to grow, they are only a symptom of some other issue. Here are some of the most common contributing factors to acne breakouts:

Poor Dietary Choices

Certain foods have been proven to cause inflammation in the body which presents itself as acne. Dairy, processed sugars, starches, and greasy food all make up a bulk of the Standard American Diet. It’s consumption of these very foods however that disrupt the gut microbiome balance and cause acne (1,2). An increase in fruits, vegetables, ancient grains, healthy fats, nuts and seeds, as well as staying hydrated can all help to stave off breakouts.

Hormonal Fluctuations

An increase in androgens (male hormones) during puberty causes elevated levels of keratinocytes and oily sebum; leading to acne. In fact, over 75% of people aged 11-30 deal with acne at some point, in varying degrees because of hormonal changes. Hormonal fluctuations women experience during their period, before/after pregnancy, and during menopause also increases sebum production.

Poor Skin Care Habits

Some skin types may react adversely to certain ingredients in skincare and makeup. This has a lot to do with our skin’s natural pH balance, which is at a healthy level between 4.5 – 5.5 (3). Unfortunately, if you apply a formula which is too acidic (below 7.0) or too alkaline (above 7.0) this can throw off your skin’s acid mantle. A disrupted acid mantle can creates a perfect environment for bacteria growth. Additionally, washing your skin too much or too little could also be the cause of acne. Excessive cleansing (or cleansing using harsh soaps and detergents) can strip your skin of natural oils and cause your skin to overproduce oil as compensation. Cleansing infrequently allows for sebum, dirt, and dead skin cells to build up within your pores and create a breeding ground for acne-causing bacteria.


Although anecdotal at the time, a 2003 study conducted at the Beth Israel Deaconess Medical Center, showed links between emotional stress and acne (4). Experiencing stress can stimulate various situations both in the body and mind. Corticotrophin-releasing hormone (CRH, a stress-related hormone), binds to the skin’s sebaceous glands which increase oil production, causing pimples, according to Dr. Adam Friedman, an associate professor of dermatology at George Washington University (5). Increased stress also contributes to poor life choices such as lack of sleep, eating junk foods, and steering away from a proper skincare routine – all of which may promote acne breakouts.


1. (2009) The relationship of diet and acne https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2836431/

2. (2011) Acne vulgaris, probiotics and the gut-brain-skin axis – back to the future? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038963/

3. (2017) Skin Surface pH in Acne Vulgaris: Insights from an Observational Study and Review of the Literature; The Journal of Clinical and Aesthetic Dermatology https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605222/

4. (2003) The Response of Skin Disease to Stress Changes in the Severity of Acne Vulgaris as Affected by Examination Stress https://jamanetwork.com/journals/jamadermatology/fullarticle/479409

5. (2017) You Asked: Can Stress Really Cause Acne? http://time.com/5014072/stress-pimples-acne/

6. (2018) Anti-Inflammatory and Skin Barrier Repair Effects of Topical Application of Some Plant Oils; International Journal of Molecular Sciences https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796020/



The product contains only natural ingredients (non-synthetic or lab created). It does not contain anything artificial or synthetic.



The product has been formulated with 100% organically sourced and/or certified organic ingredients.



This product does not contain ingredients which have been genetically modified.



All of the ingredients contained in the product are free from gluten, wheat, and ingredients which are commonly contaminated with gluten.



The product is made without animal products or byproducts such as beeswax, honey, milk, eggs, etc.



The product has received an official organic certification from a third party organization such as the United States Department of Agriculture (USDA Certified Organic), ECOCERT, Australian Certified Organic, and others.

One Response

  1. F October 25, 2019

Leave a Reply